1.基于维生素D营养和抗菌双效能的草鱼健康养殖关键技术的研发（四川省重点研发项目）

2.杀鱼爱德华氏菌通过分泌的效应物诱导铁自噬以逃逸鱼类天然免疫的机制探究（四川省中央引导地方科技发展专项项目）

3.嗜水气单胞菌效应物Hcp1靶向CaM开启和传播鱼类脾脏巨噬细胞铁死亡的机制解析（国家自然科学基金项目）

4.鱼类特有的三种IL-23异构体的鉴定及其免疫调节功能和机制探究 （国家自然科学基金项目）

5.硬骨鱼STAT3剪接异构体在免疫系统中的表达调控与功能研究（国家自然科学基金项目）

6.粘附分子EpCAM 在草鱼头肾白细胞中的功能及作用机理研究（国家自然科学基金项目）

7.TGF-beta1双向调节硬骨鱼外周血淋巴细胞活性机理的研究 （国家自然科学基金）

8.草鱼垂体中激活素对生长激素基因表达的调控：功能意义、分子机理和信号通路（国家自然科学基金）

2025

1. Ren J, Liu J, Xiong D, Wang X, Zhang A, Zhou H. Edwardsiella piscicida effector EseD induces ferritinophagy to manipulate iron homeostasis and bacterial intracellular survival via nuclear receptor coactivator 4 (NCOA4) in fish cells. Aquaculture 2025 June; 604: 742482 

2. Wang Z, Zhu M, Hu Y, Liu J, Ma X, Zhou H. Comparative effects of 6PPD and 6PPD-Quinone at environmentally relevant concentrations on hepatotoxicity, glucolipid metabolism and ferroptotic response in adult zebrafish. Environ Res. 2025 Mar; 275: 121386. 

3. Liu J, Ren J, D Wang, Wang Z, Ma X, Zhou H. Edwardsiella piscicida promotes mitophagy to escape autophagy-mediated antibacterial defense in teleost monocytes/macrophages. Aquaculture 2025 Feb; 596: 741784 

4. Yawen Wang, Jinzhi Yu, Lijun Liu, He Wei, Hong Zhou, Anying Zhang, Kun Yang, Xinyan Wang. Activation of adenosine A2a and A2b receptors augments the skin wound healing in juvenile grass carp. Aquaculture. Volume 595, Part 2, 30 January 2025, 741674

 

2024

1. Wang D, Ma X, Hu H, Ren J, Liu J, Zhou H. Functional identification of two HMGB1 paralogues provides insights into autophagic machinery in teleost. Fish Shellfish Immunol. 2024 Apr;147:109457. 

2. Sun H, Ge P, Liu J, Xiong D, Zhu M, Zhou H. Effect of dietary vitamin D3 on growth performance and functional homeostasis of particular intestinal segments in grass carp fingerlings. Aquaculture International. 2024 Feb; 32:5677–5697. 

3. Ren J, Ma X, Hu H, Wang D, Sun H, Liu J, Wang X, Zhou H. Edwardsiella piscicida causes iron storage disorders by an autophagy pathway in fish monocytes/macrophages. Fish Shellfish Immunol. 2024 Mar;146:109417 

4. Wang Y, Liu J, Xiao H, Sun H, Hu H, Ma X, Zhang A, Zhou H. Dietary intakes of vitamin D promote growth performance and disease resistance in juvenile grass carp (Ctenopharyngodon idella). Fish Physiol Biochem. 2024 Jun;50(3):1189-1203. 

5. Sun H, Ma X, Liu Q, Hu H, Wang X, Zhang A, Yang K, Yang M, Zhou H. Aeromonas hydrophila causes ferroptotic damage via its secreted effectors targeting splenic macrophages in teleost. Aquaculture. 2024 Jan; 579: 740203

 

2023

1. Sun H, Wang D, Ren J, Liu J, Wang Z, Wang X, Zhang A, Yang K, Yang M, Zhou H. Vitamin D ameliorates Aeromonas hydrophila-induced iron-dependent oxidative damage of grass carp splenic macrophages by manipulating Nrf2-mediated antioxidant pathway. Fish Shellfish Immunol. 2023 Nov;142:109145. 

2. Wang X, Zhang A, Qiu X, Yang K, Zhou H. The IL-12 family cytokines in fish: Molecular structure, expression profile and function. Dev Comp Immunol. 2023 Apr;141:104643.

 

2022

 Qiu X, Wang D, Lv M, Sun H, Ren J, Wang X, Zhou H. Identification and functional characterization of interleukin-12 receptor beta 1 and 2 in grass carp (Ctenopharyngodon idella). Mol Immunol. 2022 Jan 15;143:58-67.

 

2021

1. Qiu X, Sun H, Wang D, Ren J, Wang X, Zhang A, Yang K, Zhou H*. Stimulus-Specific Expression, Selective Generation and Novel Function of Grass Carp (Ctenopharyngodon idella) IL-12 Isoforms: New Insights Into the Heterodimeric Cytokines in Teleosts. Front Immunol. 2021 Sep 16;12:734535 

2. Yin L, Lv M, Qiu X, Wang X, Zhang A, Yang K, Zhou H*. IFN-γ Manipulates NOD1-Mediated Interaction of Autophagy and Edwardsiella piscicida to Augment Intracellular Clearance in Fish. J Immunol. 2021 Aug; 207: 1087-1098 

3. Yin L, Xu W, Liu X, Wang Y, Ge P, Wang X, Zhou H *. Autophagy promotes innate defense against Aeromonas hydrophila in grass carp (Ctenopharyngodon idella) monocytes/macrophages. Aquaculture. 2021 March; 535: 736391

2020

1. Zhang A, Jian X, Wang D, Ren J, Wang X, Zhou H*. Characterization and bioactivity of grass carp (Ctenopharyngodon idella) interleukin-21: Inducible production and involvement in inflammatory regulation. Fish Shellfish Immunol. 2020 Apr; 99:19-26. 

2. Feng S, Zhou H*, Wang Y, Qiu X, Zhang A, Wang X. Novel functions of grass carp three p40 isoforms as modulators of Th17 signature cytokine expression in head kidney leukocytes. Fish Shellfish Immunol. 2020 Mar; 98:995-1000.

 

2019

1. Feng, S., et al., Novel functions of grass carp three p40 isoforms as modulators of Th17 signature cytokine expression in head kidney leukocytes. Fish Shellfish Immunol, 2019. 

2. Yang, K., et al., Characterization of a new il-4/13 homologue in grass carp (Ctenopharyngodon idella) and its cooperation with M-CSF to promote macrophage proliferation. Fish Shellfish Immunol, 2019. 93: p. 508-516. 

3. Yin, L., et al., Functional characterization of three fish-specific interleukin-23 isoforms as regulators of Th17 signature cytokine expression in grass carp head kidney leukocytes. Fish Shellfish Immunol, 2019. 92: p. 315-321. 

4. Feng, S., et al., Production and functional insights into the potential regulation of three isoforms of grass carp p40 subunit in inflammation. Fish Shellfish Immunol, 2019. 89: p. 403-410. 

5. Zhang, S., et al., Identification and functional characterization of grass carp (Ctenopharyngodon idella) tumor necrosis factor receptor 2 and its soluble form with potentiality for targeting inflammation. Fish Shellfish Immunol, 2019. 86: p. 393-402. 

6. Wang, X., et al., Molecular characterization of grass carp interleukin-6 receptor and the agonistic activity of its soluble form in head kidney leucocytes. Fish Shellfish Immunol, 2019. 86: p. 1072-1080.

 

2018 

1. Wei, H., et al., Identification of an intercellular cell adhesion molecule-1 homologue from grass carp: Evidence for its involvement in the immune cell adhesion in teleost. Fish Shellfish Immunol, 2018. 81: p. 67-72. 

2. Wang, X., et al., Identification of two Stat3 variants lacking a transactivation domain in grass carp: New insights into alternative splicing in the modification of teleost Stat3 signaling. Fish Shellfish Immunol, 2018. 77: p. 13-21. 

3.  Yao, F., et al., Functional characterization of grass carp runt-related transcription factor 3: Involvement in TGF-beta1 mediated c-Myc transcription in fish cells. Fish Shellfish Immunol, 2018. 82: p. 130-135. 

4.  Yang, K., et al., Characterization of grass carp (Ctenopharyngodon idella) beta-defensin 1: implications for its role in inflammation control. Biosci Biotechnol Biochem, 2018: p. 1-8.

 

2017 

1. Wang, X., et al., Identification of a single p19 gene and three p40 paralogues in grass carp (Ctenopharyngodon idellus): Their potential for the formation of interleukin 23 and inducible expression in vitro and in vivo. Fish Shellfish Immunol, 2017. 71: p. 434-442. 

2. Qiu, X., et al., In vitro characterization of grass carp (Ctenopharyngodon idella) IL-26 in regulating inflammatory factors. Fish Shellfish Immunol, 2017. 66: p. 148-155. 

3. Du, L., et al., Identification and functional evaluation of two STAT3 variants in grass carp: Implication for the existence of specific alternative splicing of STAT3 gene in teleost. Dev Comp Immunol, 2017. 76: p. 326-333.

 

2016 

1. Zhang, S., et al., Identification and functional characterization of tumor necrosis factor receptor 1 (TNFR1) of grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol, 2016. 58: p. 24-32. 

2. Wang, X., et al., Grass carp TGF-beta1 impairs IL-1beta signaling in the inflammatory responses: Evidence for the potential of TGF-beta1 to antagonize inflammation in fish. Dev Comp Immunol, 2016. 59: p. 121-7. 

3. Wang, X., et al., Regulatory roles of grass carp EpCAM in cell morphology, proliferation and migration. Fish Physiol Biochem, 2016. 42(2): p. 423-30. 

4. Qin, L., et al., Lipopolysaccharide-induced autophagy participates in the control of pro-inflammatory cytokine release in grass carp head kidney leukocytes. Fish Shellfish Immunol, 2016. 59: p. 389-397.

 

2015 

1. Zhang, A., et al., Cytokine effects and cellular signaling pathways of grass carp HSP70 in head kidney leukocytes. Fish Shellfish Immunol, 2015. 46(2): p. 550-6. 

2. Yao, F., et al., Molecular and functional characterization of an IL-1beta receptor antagonist in grass carp (Ctenopharyngodon idella). Dev Comp Immunol, 2015. 49(2): p. 207-16.

3. Wei, H., et al., Dual-parallel inhibition of IL-10 and TGF-beta1 controls LPS-induced inflammatory response via NF-kappaB signaling in grass carp monocytes/macrophages. Fish Shellfish Immunol, 2015. 44(2): p. 445-52. 

4. Wang, Y., et al., Cellular activation, expression analysis and functional characterization of grass carp IkappaBalpha: evidence for its involvement in fish NF-kappaB signaling pathway. Fish Shellfish Immunol, 2015. 42(2): p. 408-12. 

5. Du, L., et al., Identification and functional characterization of grass carp IL-17A/F1: An evaluation of the immunoregulatory role of teleost IL-17A/F1. Dev Comp Immunol, 2015. 51(1): p. 202-11.

 

2014 

1. Yao, F., et al., Molecular identification of transcription factor Runx1 variants in grass carp (Ctenopharyngodon idella) and their responses to immune stimuli. Vet Immunol Immunopathol, 2014. 160(3-4): p. 201-8. 

2. Yang, X., et al., Reciprocal interaction between fish TGF-beta1 and IL-1beta is responsible for restraining IL-1beta signaling activity in grass carp head kidney leukocytes. Dev Comp Immunol, 2014. 47(2): p. 197-204. 

3. Wei, H., et al., Identification of grass carp IL-10 receptor subunits: functional evidence for IL-10 signaling in teleost immunity. Dev Comp Immunol, 2014. 45(2): p. 259-68. 

4. Du, L., et al., Characterization of grass carp (Ctenopharyngodon idella) IL-17D: molecular cloning, functional implication and signal transduction. Dev Comp Immunol, 2014. 42(2): p. 220-8.

 

2013 

1. Yang, X., et al., Molecular and functional characterization of IL-1 receptor type 2 in grass carp: a potent inhibitor of IL-1beta signaling in head kidney leukocytes. Dev Comp Immunol, 2013. 41(4): p. 738-45. 

2. Yang, K., et al., IFN-gamma-activated lymphocytes boost nitric oxide production in grass carp monocytes/macrophages. Fish Shellfish Immunol, 2013. 35(5): p. 1635-41. 

3. Wei, H., et al., Functional expression and characterization of grass carp IL-10: an essential mediator of TGF-beta1 immune regulation in peripheral blood lymphocytes. Mol Immunol, 2013. 53(4): p. 313-20. 

4. Wang, X., et al., Evidence for pituitary adenylate cyclase-activating peptide as a direct immunoregulator in teleost head kidney. Fish Shellfish Immunol, 2013. 34(1): p. 265-72.

 

2012 

1. Zhao, T., et al., Molecular and functional characterization of grass carp squint/nodal-related 1: a potential regulator of activin signaling in teleost pituitary cells. Domest Anim Endocrinol, 2012. 42(4): p. 239-48. 

2. Zhang, A., et al., Functional characterization of TNF-alpha in grass carp head kidney leukocytes: induction and involvement in the regulation of NF-kappaB signaling. Fish Shellfish Immunol, 2012. 33(5): p. 1123-32. 

3. Zeng, F., et al., Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression. Med Oncol, 2012. 29(4): p. 2519-26. 

4. Yang, M., et al., Characterization of Foxp3 gene from grass carp (Ctenopharyngodon idellus): a rapamycin-inducible transcription factor in teleost immune system. Dev Comp Immunol, 2012. 38(1): p. 98-107. 

5. Yang, M., et al., TGF-beta1 exerts opposing effects on grass carp leukocytes: implication in teleost immunity, receptor signaling and potential self-regulatory mechanisms. PLoS One, 2012. 7(4): p. e35011.

 

2011 

1. Zhang, A., et al., Characterization of two heat shock proteins (Hsp70/Hsc70) from grass carp (Ctenopharyngodon idella): evidence for their differential gene expression, protein synthesis and secretion in LPS-challenged peripheral blood lymphocytes. Comp Biochem Physiol B Biochem Mol Biol, 2011. 159(2): p. 109-14. 

2. Xu, J.X., et al., Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia. Am J Chin Med, 2011. 39(1): p. 65-81. 

3. Wang, X., et al., Regulation of dopamine D2 receptor expression in grass carp pituitary cells: a possible mechanism for dopaminergic modification of luteinizing hormone synthesis. Gen Comp Endocrinol, 2011. 173(1): p. 48-55.

 

2010 

1.     Yang, M., et al., Characterization of grass carp (Ctenopharyngodon idellus) Foxp1a/1b/2: evidence for their involvement in the activation of peripheral blood lymphocyte subpopulations. Fish Shellfish Immunol, 2010. 28(2): p. 289-95. 

2. Wang, X., et al., A newly identified epithelial cell adhesion molecule (EpCAM) from grass carp (Ctenopharyngodon idellus): cloning, tissue distribution and lipopolysaccharide-induced expression in head kidney leucocytes. Fish Shellfish Immunol, 2010. 29(6): p. 998-1002. 

3. Song, C., X. Wang, and H. Zhou, Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells. Gen Comp Endocrinol, 2010. 166(1): p. 211-6.

 

2009

Chen, C., et al., Molecular cloning, characterization and tissue distribution of six splice variants of activin type IIA receptor (ActRIIA) from grass carp (Ctenopharyngodon idellus). Genes Genet Syst, 2009. 84(5): p. 335-44. 

2008 

Wang, Z., et al., High-level expression, purification, and characterization of the recombinant grass carp pituitary adenylate cyclase-activating polypeptide. Biosci Biotechnol Biochem, 2008. 72(6): p. 1550-7.