This First/corresponding Author

2022年

 Journal Papers期刊论文：

[1] FI. Khan, F. Hassan, D. Lai^*, "In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor," Frontiers in Immunology, vol 12, Article ID 794780, Jan, 2022. (JCR 2, IF 7.561)

[2] FI. Khan, Lobb K, D. Lai^*, "The Molecular Basis of the Effect of Temperature on the Structure and function of SARS-CoV-2 Spike Protein," Frontiers in Molecular Biosciences, Mar. 2022, (Early Access, DOI: 10.3389/fmolb.2022.794960, ISSN 2296-889X.) (JCR 2, IF 5.246)

[3] FI. Khan, MT. Rehman, F. Sameena, T. Hussain, MF. AlAjmi, D. Lai^*, and MKA. Khan*, "Investigating the binding mechanism of topiramate with bovine serum albumin using spectroscopic and computational methods," Journal of Molecular Recognition, (Early Access, DOI: 10.1002/jmr.2958.794960, ISSN 1099-1352.) (JCR 4, IF 2.137)

[4] H. Ullah, MBB. Heyat, A. Gumaei*, Y. Lin*,  D. Lai^*,  et. al, “An Effective and Lightweight Deep Electrocardiography  Arrhythmia Recognition Model Using Novel Special and Native Structural  Regularization Techniques on Cardiac Signal,” Journal of Healthcare Engineering, vol. 2022, Article 3408501, pp.1-18, 2022.  (JCR 4, IF 2.682)

[5] J. Rani, A. Bhargav, FI. Hassan, S. Ramachandran^*, D. Lai^*, U. Bajpai^*, "In silico prediction of natural compounds as potential multi-target inhibitors of structural proteins of SARS-CoV-2," Journal of Biomolecular Structure & Dynamics, Aug. 2021 (Early Access, DOI: 10.1080/07391102.2021.1968497).

[6] 卜雨翔，茶兴增，朱金灵，苏叶，赖大坤*，“基于深度卷积神经网络的肥厚型心肌病自动检测模型，”生物医学工程学杂志，vol. 39, no. 2, pp.285-292, 2022.

  Conference Papers会议论文：

2021年

 Journal Papers期刊论文：

[1] Md Belal Bin Heyat, Faijan Akhtar, Masood Hasan Khan, Najeeb Ullah, Ijaz Gul, Haroon Khan^*, Dakun Lai^*,  “Detection,  Treatment Planning, and Genetic Predisposition of Bruxism:  A Systematic Mapping Process and Network Visualization Technique” in  CNS & Neurological Disorders - Drug Targets, vol. 20, no.8, pp. 755-775, Oct. 2021. (JCR 2, IF 4.388)

[2] FI. Khan, T. Kang, H. Ali, D. Lai^*,  “Remdesivir Strongly Binds to RNA-Dependent RNA Polymerase, Membrane  Protein, and Main Protease of SARS-CoV-2: Indication From Molecular  Modeling and Simulations”, Frontiers in Pharmacology, vol. 12, Article 710778, Jul. 2021. (JCR 2, IF 5.810)

[3] D. Lai^*,  X. Fan, Y. Zhang and W. Chen, "Intelligent and Efficient Detection of  Life-Threatening Ventricular Arrhythmias in Short Segments of Surface  ECG Signals," in IEEE Sensors Journal. vol. 21, no. 13, pp. 14110-14120, Jul. 2021. (JCR 3, IF 3.301)

[4] Y. Bu, M. F. U. Hassan and D. Lai^*, "The Embedding of Flexible Conductive Silver-Coated Electrodes into ECG Monitoring Garment for Minimizing Motion Artefacts," in IEEE Sensors Journal. vol. 21, no. 12, pp. 14454-14465, Jul. 2021. (JCR 3, IF 3.301)

[5] FI. Khan, HH. Song, F. Hassan., J. Feng, LX. Tang, D. Lai^*,  F. Juan*, "Impact of amino acid substitutions on the behavior of a  photoactivatable near infrared fluorescent protein PAiRFP1," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 253, Article ID 119572, May 2021. (JCR 3, IF 4.098)

[6] Md BB. Heyat, F. Akhtar, M.A. Ansari, A. Khan, F. Alkahtani, H. Khan^*, D. Lai^*, “Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review”， Current Drug Targets, vol. 22, no. 6, pp. 672-684, 2021. (JCR 3, IF 3.465)

[7] FI. Khan, S. Ali, W. Chen, F. Anjum, A. Shafie, I. Hassan, D. Lai^*,  “High-resolution  MD simulation studies to get mechanistic insights  into the urea-induced  denaturation of human Sphingosine kinase 1”, Current Topics in Medicinal Chemistry, vol. 21, no. 31, pp.2839-2850, 2021. (JCR 3, IF 3.295)

[8] FI. Khan, FI. Hassan, D. Lai^*, "Mechanism of pH-induced conformational changes in MurE ligase obtained from Salmonella enterica serovar Typhi," Journal of Biomolecular Structure & Dynamics, vol. 39, no. 5, pp.1898-1905, 2021.

[9] 康同舟，左润东，钟岚烽，陈文静，张恒，刘红秀，赖大坤*，“基于双密度双树复小波变换的癫痫发作期自动检测算法，”生物医学工程学杂志，vol. 38, no. 6, pp.1-10, 2021.12.

  Conference Papers会议论文：

[1]  H. Ullah, Y. Bu, T. Pan, M, Gao, S. Islam, Y. Lin*, D. Lai^*, "Cardiac Arrhythmia Recognition Using Transfer Learning with a Pre-trained DenseNet"[C], 2020 IEEE 2^nd International Conference on  Pattern Recognition and Machine Learning (PRML 2021)，Chengdu, pp. 347-353, China.

2020年

 Journal Papers期刊论文：

[1]  D. Lai^*,   Y. Bu, Y. Su, X. Zhang and C. Ma, "Non-Standardized Patch-Based ECG   Lead Together With Deep Learning Based Algorithm for Automatic  Screening  of Atrial Fibrillation," in IEEE Journal of Biomedical and Health Informatics, vol. 24, no. 6, pp. 1569-1578, June 2020. (JCR 2, IF 5.772)

[2]  FI. Khan , D. Lai^*, Anwer R, et al. "Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer," Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 35, no.1, pp. 172-186, Jan. 2020. (JCR 2, IF 4.673)

[3] FI. Khan, P. Gupta, AM. Asiri, D. Lai^*, et al., "Mechanistic insights into the urea-induced denaturation of human sphingosine kinase 1," in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES，vol.161, pp. 1496-1505, Oct. 2020. (JCR 2, IF 6.953)

[4] FI. Khan, F. Hassan, R. Anwer, F. Juan, and D.Lai ^*, "Comparative  Analysis of Bacteriophytochrome Agp2 and Its  Engineered Photoactivatable NIR Fluorescent Proteins PAiRFP1 and  PAiRFP2," Biomolecules, vol. 10, no. 9, pp.1286, 2020. (JCR 2, IF 4.879) 

[5]  D. Lai^*,  X. Zhang, W. Chen, H. Zhang, T. Kang, H. Yuan, L. Ding, "Channel-Wise  Characterization of High Frequency Oscillations for Automated  Identification of the Seizure Onset Zone," in IEEE Access, vol. 8, pp. 45531-45543, 2020. (JCR 2, IF 3.745)     

[6]  D. Lai^*,  Y. Bu, Y. Su, X. Zhang and C. Ma, "A Flexible Multilayered Dry  Electrode and Assembly to Single-Lead ECG Patch to Monitor Atrial  Fibrillation in a Real-Life Scenario," in IEEE Sensors Journal, vol. 20, no. 20, pp. 12295-12306, Oct.15, 2020. (JCR 3, IF 3.301)

[7] MBB. Heyat, D. Lai*, et al., "A Novel Hybrid Machine Learning Classification for the Detection of Bruxism Patients Using Physiological Signals," in Applied Sciences-Basel, vol. 10, no. 21, Article ID. 7410, Nov., 2020. (JCR 3, IF 2.679)

[8]  Hassan F, Khan F I, Song H, Lai D.^*,   et al. Effects of reverse genetic mutations on the spectral and   photochemical behavior of a photoactivatable fluorescent protein   PAiRFP1," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 228, Article ID. 117807, Mar. 2020. (JCR 3, IF 3.232)

Conference Papers会议论文：

[1]  X. Fan, Y. Bu, D. Lai^*. “A Neural-Network Model for Deriving Analogous Three-vector ECGs of S-ICD from Standard Nine-lead ECGs”[C]， 2020 International Conference on Pattern Recognition and Machine Learning (PRML 2020), Chengdu, China.

[2] D. Lai^*,  Y. Zhang and X. Zhang, "Single Lead ECG-based Ventricular  Repolarization Classification for Early Identification of Unexpected  Ventricular Fibrillation*," 2020 42^nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 2020, pp. 5567-5570.

[3]   D. Lai^*,  L. Mao, Q. Xu and J. Li, "A Novel Reconstruction Method with Time  Reversal Algorithm and Evaluations for Photoacoustic Tomography," 2020 42^nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 2020, pp. 1923-1926.

[4]  D. Lai^*,  F. Ding, C. Xie and Y. Zhang, "An Adaptive Respiratory Motion  Compensation Algorithm with Singular Value Decomposition for  Intracardiac Catheter Tracking*,"2020 42^nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Montreal, QC, Canada, 2020, pp. 5065-5068.

2019年

 Journal Papers期刊论文：

[1]  D. Lai^*,  X. Zhang, Y. Bu, Y. Su and C. Ma, "An Automatic System for  Real-Time Identifying Atrial Fibrillation by Using a Lightweight  Convolutional Neural Network," in IEEE Access, vol. 7, pp. 130074-130084, 2019. (JCR 2, IF 4.098)

[2] D. Lai^*,   Y. Zhang, X. Zhang, Y. Su and M. B. Bin Heyat, "An Automated Strategy  for Early Risk Identification of Sudden Cardiac Death by Using Machine  Learning Approach on Measurable Arrhythmic Risk Markers," in IEEE  Access, vol. 7, pp. 94701-94716, 2019. (JCR 2, IF 4.098)

[3] D. Lai^*,  X. Zhang, F. Ma, Z. Chen, et al., "Automated Detection of High   Frequency Oscillations in Intracranial EEG Using the Combination of   Short-Time Energy and Convolutional Neural Networks," in IEEE Access, vol. 7, pp. 82501-82511, 2019. (JCR 2, IF 4.098)

[4]   MBB. Heyat, D. Lai^*,  FI. Khan and Y. Zhang, "Sleep Bruxism Detection Using Decision Tree   Method by the Combination of C4-P4 and C4-A1 Channels of Scalp EEG," in IEEE Access, vol. 7, pp. 102542-102553, 2019. (JCR 2, IF 4.098)

[5]  D. Lai^*,   MBB. Heyat, FI. Khan and Y. Zhang, "Prognosis of Sleep Bruxism  Using  Power Spectral Density Approach Applied on EEG Signal of Both  EMG1-EMG2  and ECG1-ECG2 Channels," in IEEE Access, vol. 7, pp. 82553-82562, 2019. (JCR 2, IF 4.098)

  Conference Papers会议论文：

[1]    D. Lai^*,  X. Zhang, Y. Zhang and M. B. Bin Heyat, "Convolutional Neural Network  Based Detection of Atrial Fibrillation Combing R-R intervals and F-wave  Frequency Spectrum *,"2020 41^st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany, 2019, pp. 4897-4900.

[2]  D. Lai^*,  X. Fan and Q. Chen, "A Numerical Evaluation of Multi-Lead Subcutaneous  Implantable Cardioverter Defibrillator for Low Energy and Less Damage in  Swine*," 2020 41^st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany, 2019, pp. 4889-4892.

[3]  K. Ma, D. Lai^*,  et al., "Automatic detection of High Frequency Oscillations (80-500Hz)  based on Convolutional Neural Network in Human Intracerebral  Electroencephalogram *," 2020 41^st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Berlin, Germany, 2019, pp. 5133-5136.

[4]   Muhammad Faiz ul Hassan, Dakun Lai^*, Yuxiang Bu, "Characterization of Single Lead Continuous ECG Recording with Various Dry Electrodes," 2019 3^rd International Conference on Computational Biology and Bioinformatics, Nagoya, Japan, 2019, pp.76-79.

2018年及之前

  Journal Papers期刊论文：

[1]   Q. Xu, B. Chen, P. Li, J. Liu, Dakun Lai^*, “Piezoelectric  Micromachined Ultrasonic Transducers for Photoacoustic Imaging:  Modeling and Simulation of Structural P arameters on Receiving  Performance," X-Acoustics: Imaging and Sensing, 2015.

[2]  Lai D, Sun J, Li Y, He B.^*,  "Usefulness of ventricular endocardial electric reconstruction from  body surface potential maps to noninvasively localize ventricular  ectopic activity in patients," Phys. Med. Biol., vol. 58, no. 11, pp.3897-3909, 2013. (UMN)

[3] Y. Long, Lai D., Sun J, He B.^*, "Noninvasive Cardiac Activation Imaging of Premature Ventricular Contractions in Human Patients," Circulation, vol. 126, no. 21, Nov. 2012. (UMN)

[4]  Lai D, Liu C, Eggen MD, Iaizzo PA, He B.^* , "Localization of endocardial ectopic activity by means of noninvasive endocardial surface current density reconstruction," Phys. Med. Biol., vol. 56, no.13, pp.4161-4176, 2011. (UMN)

[5]    D. Lai, C. Liu, M. D. Eggen, P. A. Iaizzo and B. He^*, "Equivalent Moving Dipole Localization of Cardiac Ectopic Activity in a Swine Model During Pacing," in IEEE Transactions on Information Technology in Biomedicine," vol. 14, no. 6, pp. 1318-1326, Nov. 2010. (UMN)

 Conference Papers会议论文：

[1]    D. Lai^*,  Z. Kan, W. Chen and H. Zhang, "High Frequency Oscillations Detection in  Patients Combining Wavelet Decomposition and Back Propagation Neural  Network," 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS),  Cleveland, OH, 2018, pp. 1-4.

[2]    L. Mao, D. Lai^*,  Q. Xu and C. Xie, "Photoacoustic imaging: A potential new tool for  diagnosing vasculogenic erectile dysfunction," 2016 9th International  Congress on Image and Signal Processing, BioMedical Engineering and  Informatics (CISP-BMEI), Datong, 2016, pp. 1365-1369.

[3]    H. Zhang, D. Lai^*,  C. Xie, H. Zhang and W. Chen, "Directed-transfer-function based  analysis for epileptic prediction," 2016 9th International Congress on  Image and Signal Processing, BioMedical Engineering and Informatics  (CISP-BMEI), Datong, 2016, pp. 1487-1491.

[4]    J. Liu, L. Mao, D. Lai^*  and G. Liu, "A Novel Reconstruction Method of Magnetoacoustic  Tomography with Magnetic Induction Based on the Amplitude of Lorentz  Force," 2016 3rd International Conference on Information Science and  Control Engineering (ICISCE), Beijing, 2016, pp. 88-90.

[5]  Q. Xu and D. Lai^*,  "Piezoelectric micromachined ultrasonic transducers: Modeling and  simulation of structural parameters on transmitting performance," 2015  IEEE Advanced Information Technology, Electronic and Automation Control  Conference (IAEAC), Chongqing, 2015, pp. 648-652.

[6]    D. Lai^*,  P. Li and Q. Xu, "A multi-criteria evaluation method for assessing the  defibrillation outcome of different electrode placements in swine," 2015  37th Annual International Conference of the IEEE Engineering in  Medicine and Biology Society (EMBC), Milan, 2015, pp. 4507-4510.

[7]    D. Lai^*,  F. Zhang and C. Wang, "A real-time QRS complex detection algorithm  based on differential threshold method," 2015 IEEE International  Conference on Digital Signal Processing (DSP), Singapore, 2015, pp.  129-133.

[8]   P. Li, D. Lai^*,  F. Zhang and T. Feng, "Numerical modeling and simulation based on  finite element method for internal cardiac defibrillation in a human  torso," 2014 7th International Conference on Biomedical Engineering and  Informatics, Dalian, 2014, pp. 456-460.

[9]    Fei  Zhang, Pengye Li, Fan Jiang and Dakun Lai, "A shockable rhythm  detection algorithm for automatic external defibrillators by combining a  slope variability analyzer with a band-pass digital filter," 2014 IEEE  Workshop on Electronics, Computer and Applications, Ottawa, ON, 2014,  pp. 828-831.

[10] D. Lai, C. Liu, M. D. Eggen, P. A. Iaizzo and B. He^*,  "Cardiac source localization by means of a single moving dipole  solution during endocardial pacing in an animal model," 2009 Annual  International Conference of the IEEE Engineering in Medicine and Biology  Society, Minneapolis, MN, 2009, pp. 1778-1780. (UMN)

[11] Z. Fang, D. Lai, X. Ge and X. Wu^*,  "Successive ECG telemetry monitoring for preventing sudden cardiac  death," 2009 Annual International Conference of the IEEE Engineering in  Medicine and Biology Society, Minneapolis, MN, 2009, pp. 1738-1741.(UMN)

[12] X. Ge, D. Lai, X. Wu and Z. Fang^*,  "A novel non-model-based 6-DOF electromagnetic tracking method using  non-iterative algorithm," 2009 Annual International Conference of the  IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, 2009,  pp. 5144-5117.(UMN)

[13] D. Lai, T. Cao and Z. Fang^*,  "Modeling and Simulation of Three Orthogonal Transthoracic  Electrical-Fields for Localization Method of Intracardiac Catheter,"  2008 2nd International Conference on Bioinformatics and Biomedical  Engineering, Shanghai, 2008, pp. 1461-1463. (Fudan)

[14] X. Ge, D. Lai, X. Wu and Z. Fang^*,  "A Real-Time Continuous ECG Transmitting Method through GPRS with Low  Power Consumption," 2008 2nd International Conference on Bioinformatics  and Biomedical Engineering, Shanghai, 2008, pp. 556-559.(Fudan)

[15] D. Lai and Z. Fang^*,  "Real-Time Remote Monitoring of Out-of-Hospital Patients Especially  with High Risk Heart Diseases," 2007 IEEE/ICME International Conference  on Complex Medical Engineering, Beijing, 2007, pp. 332-335.(Fudan)

一、柔性生物电检测及人工智能分析 Flexible Bioelectric Measurement and Automatic Diagonsis with AI：

     1、柔性生物电干电极技术

     2、心律失常心电自动分析与诊断

     3、癫痫脑电自动分析与病灶定位

     4、睡眠/疲劳状态监测

二、生物电磁效应与多物理场成像 Bioeletromagnetic Efficacy and Multi-Physical Imaging：

     1、心脏电除颤效应与正问题研究

     2、心电功能源定位与反问题研究

     3、生物组织光声/热声/磁声成像

     4、物质结构微波/毫米波/太赫兹成像

三、计算生物医学与数值模拟方法 Computational Biomedical Analysis and Numerical Modeling：

     1、分子/细胞级模拟与构效分析

     2、心/脑电生理模拟与机理分析